The effects of methylamine osmolytes on the cytoskeleton microtubule assembly
نویسنده
چکیده
16 Introduction 17 Materials and Methods 20 Results 23 Discussion 33 Acknowledgments 37 References 37 CHAPTER 3: TRIMTHYLAMINE N-OXIDE CAN PROMOTE 39 PHOSPHORYLATED TAU-TUBULIN ASSEMBLY Abstract 39 Introduction 41 Materials and Methods 4439 Introduction 41 Materials and Methods 44
منابع مشابه
Testing the Ability of Non-Methylamine Osmolytes Present in Kidney Cells to Counteract the Deleterious Effects of Urea on Structure, Stability and Function of Proteins
Human kidney cells are under constant urea stress due to its urine concentrating mechanism. It is believed that the deleterious effect of urea is counteracted by methylamine osmolytes (glycine betaine and glycerophosphocholine) present in kidney cells. A question arises: Do the stabilizing osmolytes, non-methylamines (myo-inositol, sorbitol and taurine) present in the kidney cells also countera...
متن کاملSalt Potentiates Methylamine Counteraction System to Offset the Deleterious Effects of Urea on Protein Stability and Function
Cellular methylamines are osmolytes (low molecular weight organic compounds) believed to offset the urea's harmful effects on the stability and function of proteins in mammalian kidney and marine invertebrates. Although urea and methylamines are found at 2:1 molar ratio in tissues, their opposing effects on protein structure and function have been questioned on several grounds including failure...
متن کاملInfluence of TMAO and urea on the structure of water studied by inelastic X-ray scattering.
We present a study on the influence of the naturally occurring organic osmolytes tri-methylamine N-oxide (TMAO) and urea on the bulk structure of water using X-ray Raman scattering spectroscopy. Addition of TMAO is known to stabilize proteins in otherwise destabilizing aqueous urea solutions. The experimental X-ray Raman scattering spectra change systematically with increasing solute concentrat...
متن کاملOsmolitos cosmotropos impedem a desnaturação das proteínas
Venkatesu P, Lee MJ, Lin HM. J Phys Chem B. 2009 Apr 16;113(15):5327-38 Department of Chemical Engineering, National Taiwan University of Science and Technology, 43 Keelung Road, Section 4, Taipei 106-07, Taiwan. The stability of proteins is reduced by urea, which is methylamine and nonprotecting osmolyte; eventually urea destabilizes the activity and function and alters the structure of protei...
متن کاملCompatible and counteracting solutes: protecting cells from the Dead Sea to the deep sea.
Cells of many organisms accumulate certain small organic molecules--called compatible and counteracting solutes, compensatory solutes, or chemical chaperones--in response to certain physical stresses. These solutes include certain carbohydrates, amino acids, methylamine and methylsulphonium zwitterions, and urea. In osmotic dehydrating stress, these solutes serve as cellular osmolytes. Unlike c...
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تاریخ انتشار 2015